cis-1,1,1,4,4,4-hexafluorobut-2-ene / HFO-1336mzz(Z)

cis-1,1,1,4,4,4-hexafluorobut-2-ene / HFO-1336mzz(Z)

692-49-9

Synquest

https://synquestprodstorage.blob.core.windows.net/msds/1300/1300-3-Z6.pdf

2017

Refrigerant gas

Karen_Thomas1@uml.edu

Yes

66

8.00

9

9

8

10

4

6

10

{"1":{"value":"690413","score":2,"memo":"LC50 (Rat): Test Guideline 403"},"5":{"value":"4","score":4},"7":{"value":"4","score":4,"memo":"SciFinder"},"16":{"value":"4","score":4,"memo":"STOT SE 3 H335 - May cause respiratory irritation"},"17":{"value":"4","score":4,"memo":"SDS"},"19":{"value":"8","score":8,"memo":"Causes skin irritation"},"20":{"value":"6","score":6,"memo":"SDS"},"21":{"value":"8","score":8,"memo":"SDS Causes skin irritation"},"22":{"value":"10","score":10,"memo":"Causes serious eye irritation"},"23":{"value":"8","score":8,"memo":"SDS"},"24":{"value":"8","score":8},"25":{"value":"500","score":2,"memo":"US WEEL - Chemours"},"45":{"value":"6","score":6,"memo":"STOT SE 3 H336 - May cause drowsiness or dizziness"},"48":{"value":"6","score":6,"memo":"STOT SE 3 H336 - May cause drowsiness or dizziness"},"47":{"value":"6","score":6,"memo":"STOT SE 3 H336 - May cause drowsiness or dizziness"},"46":{"memo":"May cause cardiac arrhythmia. Other symptoms potentially related to misuse or inhalation abuse are Cardiac sensitization Anaesthetic effects Light-headedness Dizziness confusion Lack of coordination Drowsiness Unconsciousness"},"61":{"value":"6","score":6,"memo":"STOT SE 3 H335 - May cause respiratory irritation"},"60":{"memo":"May cause cardiac arrhythmia. Other symptoms potentially related to misuse or inhalation abuse are Cardiac sensitization Anaesthetic effects Light-headedness Dizziness confusion Lack of coordination Drowsiness Unconsciousness"},"29":{"value":"8","score":8,"memo":"SDS"},"33":{"value":"2","score":2},"34":{"value":"2","score":2},"38":{"value":"2","score":2,"memo":"Test Type: OECD Test Guideline 47"},"39":{"value":"2","score":2},"40":{"value":"2","score":2},"41":{"value":"2","score":2,"memo":"Test Type: (AMES) Method: OECD Test Guideline 471 Result: negative"},"42":{"value":"2","score":2},"43":{"value":"2","score":2},"44":{"value":"2","score":2},"55":{"value":"10","score":10,"memo":"SIN Groups"},"59":{"value":"8","score":8,"memo":"STOT SE 3 H335 - May cause respiratory irritation"},"64":{"value":"12.3","score":6,"memo":"QSAR toolbox v4.6 - Read-across analysis, Automated workflow for Fish, LC50(EC50) at 96h for Pimephales promelas (mortality)"},"65":{"value":"3.8","score":8,"memo":"QSAR toolbox v4.6 - Trend analysis - Ecotoxicological Information -> Aquatic Toxicity -> Population -> EC50 -> 72 h -> Plantae (plants) -> Chlorophyta (green algae) -> Chlorophyceae"},"66":{"value":"6","score":6},"67":{"value":"6","score":6},"68":{"value":"6","score":6},"70":{"value":"2.16","score":6,"memo":"EPI Suite"},"71":{"value":"6","score":6},"72":{"value":"6","score":6},"73":{"value":"6","score":6},"75":{"value":"8","score":8},"76":{"value":"8","score":8,"memo":"Aquatic Chronic 2 - Toxic to aquatic life with long lasting effects (modeled) DK-EPA - Danish Advisory List Danish Environmental Protection Agency (DK-EPA)"},"79":{"value":"8","score":10,"memo":"EPI Suite"},"77":{"value":"60","score":10,"memo":"EPI Suite"},"81":{"value":"120","score":10,"memo":"EPI Suite"},"83":{"value":"10","score":10,"memo":"Extremely persistent ChemSec - SIN List ChemSec, The International Chemical Secretariat"},"88":{"value":"10","score":10,"memo":"Extremely persistent ChemSec - SIN List ChemSec, The International Chemical Secretariat"},"89":{"value":"2.3","score":2},"90":{"value":"82.77","score":2,"memo":"EPI Suite"},"92":{"value":"4","score":4},"93":{"value":"1.58","score":6,"memo":"https:\/\/www.ecfr.gov\/current\/title-40\/chapter-I\/subchapter-C\/part-98\/subpart-A\/appendix-Table%20A-1%20to%20Subpart%20A%20of%20Part%2098"},"94":{"value":"2","score":2},"96":{"value":"2","score":2},"97":{"value":"2","score":2},"99":{"value":"2","score":2},"98":{"value":"2","score":2},"101":{"value":"2","score":2},"100":{"value":"2","score":2},"102":{"value":"1013","score":10},"103":{"value":"2","score":2,"memo":"SDS"},"107":{"memo":"ASTM D 56 boils before flash"},"108":{"value":"2","score":2,"memo":"Lower flammability limit Method: ASTM E681 None."},"109":{"value":"2","score":2,"memo":"Lower flammability limit Method: ASTM E681 None."},"110":{"value":"2","score":2,"memo":"Protect from sunlight. Do not expose to temperatures exceeding 50 \u2103. Keep away from heat, sparks and flame."},"113":{"value":"","score":""},"114":{"value":"2","score":2},"115":{"value":"2","score":2},"116":{"value":"2","score":2},"117":{"value":"2","score":2},"153":{"value":"10","score":10},"146":{"value":"10","score":10},"147":{"value":"6","score":6},"150":{"value":"100","score":2}}

690413

LC50 (Rat): Test Guideline 403

4

4

SciFinder

4

STOT SE 3 H335 - May cause respiratory irritation

4

SDS

8

Causes skin irritation

6

SDS

8

SDS Causes skin irritation

10

Causes serious eye irritation

8

SDS

8

500

US WEEL - Chemours

8

SDS

2

2

2

Test Type: OECD Test Guideline 47

2

2

2

Test Type: (AMES) Method: OECD Test Guideline 471 Result: negative

2

2

2

6

STOT SE 3 H336 - May cause drowsiness or dizziness

May cause cardiac arrhythmia. Other symptoms potentially related to misuse or inhalation abuse are Cardiac sensitization Anaesthetic effects Light-headedness Dizziness confusion Lack of coordination Drowsiness Unconsciousness

6

STOT SE 3 H336 - May cause drowsiness or dizziness

6

STOT SE 3 H336 - May cause drowsiness or dizziness

10

SIN Groups

8

STOT SE 3 H335 - May cause respiratory irritation

May cause cardiac arrhythmia. Other symptoms potentially related to misuse or inhalation abuse are Cardiac sensitization Anaesthetic effects Light-headedness Dizziness confusion Lack of coordination Drowsiness Unconsciousness

6

STOT SE 3 H335 - May cause respiratory irritation

12.3

QSAR toolbox v4.6 - Read-across analysis, Automated workflow for Fish, LC50(EC50) at 96h for Pimephales promelas (mortality)

3.8

QSAR toolbox v4.6 - Trend analysis - Ecotoxicological Information -> Aquatic Toxicity -> Population -> EC50 -> 72 h -> Plantae (plants) -> Chlorophyta (green algae) -> Chlorophyceae

6

6

6

2.16

EPI Suite

6

6

6

8

8

Aquatic Chronic 2 - Toxic to aquatic life with long lasting effects (modeled) DK-EPA - Danish Advisory List Danish Environmental Protection Agency (DK-EPA)

60

EPI Suite

8

EPI Suite

120

EPI Suite

10

Extremely persistent ChemSec - SIN List ChemSec, The International Chemical Secretariat

10

Extremely persistent ChemSec - SIN List ChemSec, The International Chemical Secretariat

2.3

82.77

EPI Suite

4

1.58

https://www.ecfr.gov/current/title-40/chapter-I/subchapter-C/part-98/subpart-A/appendix-Table%20A-1%20to%20Subpart%20A%20of%20Part%2098

2

0

2

2

2

2

2

2

1013

2

SDS

ASTM D 56 boils before flash

2

Lower flammability limit Method: ASTM E681 None.

2

Lower flammability limit Method: ASTM E681 None.

2

Protect from sunlight. Do not expose to temperatures exceeding 50 ℃. Keep away from heat, sparks and flame.

2

2

2

2

10

6

100

10